Publications

Publications

DRC Publications Highlights

DRC researchers publish high-impact studies related to a wide range of issues relevant to dementia.

See all DRC publications

Year 2024

Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice

Ke, Y. D., van Hummel, A., Au, C., Chan, G., Lee, W. S., van der Hoven, J., Przybyla, M., Deng, Y., Sabale, M., Morey, N., Bertz, J., Feiten, A., Ippati, S., Stevens, C. H., Yang, S., Gladbach, A., Haass, N. K., Kril, J. J., Blair, I. P., Delerue, F., & 1 others, 17 Apr 2024, In: Neuron. 112, 8, p. 1249-1264.e8 25 p.

doi: 10.1016/j.neuron.2024.01.022.

Epub 2024 Feb 15

Year 2023

Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy

Shelley L Forrest, Seojin Lee, Nasna Nassir, Ivan Martinez-Valbuena, Valerie Sackmann, Jun Li, Awab Ahmed, Maria Carmela Tartaglia, Lars M Ittner, Anthony E Lang, Mohammed Uddin, Gabor G Kovacs

Acta Neuropathologica 2023 Sep;146(3):395-414. Epub 2023 Jun 24.

DOI: 10.1007/s00401-023-02604-x.

SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity

Martínez-Mármol R, Giordano-Santini R, Kaulich E, Cho AN, Przybyla M, Riyadh MA, Robinson E, Chew KY, Amor R, Meunier FA, Balistreri G, Short KR, Ke YD, Ittner LM, Hilliard MA.
Sci Adv. 2023 Jun 9;9(23):eadg2248. doi: 10.1126/sciadv.adg2248. Epub 2023 Jun 7.

    Year 2022

    Treatment of epilepsy using a targeted p38γ kinase gene therapy

    Sci Adv. 2022 Dec 2;8(48):eadd2577. doi: 10.1126/sciadv.add2577. Epub 2022 Dec 2.

    Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease

    Published: 3 July 2022

    Acta Neuropathologica (2022) DOI: 10.1007/s00401-022-02457-w

    Biomarker discovery and development for frontotemporal dementia and amyotrophic lateral sclerosis

    Katzeff, J. S., Bright, F., Phan, K., Kril, J. J., Ittner, L. M., Kassiou, M., Hodges, J. R., Piguet, O., Kiernan, M. C., Halliday, G. M. & Kim, W. S., 3 Jun 2022
    Brain. 145, 5, p. 1598-1609 12 p. DOI: 10.1093/brain/awac077

    Year 2021

    Rapid initiation of cell cycle reentry processes protects neurons from amyloid-β toxicity

    Stefania Ippati, Yuanyuan Deng, Julia van der Hoven, Celine Heu, Annika van Hummel, Sook Wern Chua, Esmeralda Paric, Gabriella Chan, Astrid Feiten, Thomas Fath, Yazi D. Ke, Nikolas K. Haass, Lars M. Ittner

    PNAS March 23, 2021 118 (12) e2011876118; https://doi.org/10.1073/pnas.2011876118

    Globular glial tauopathy with a mutation in MAPT and unusual TDP-43 proteinopathy in a patient with behavioural-variant frontotemporal dementia

    Forrest, S. L., Shepherd, C. E., McCann, H., Kwok, J. B., Halliday, G. M. & Kril, J. J., May 2021,

    Acta Neuropathologica. 141, 5, p. 791-794 4 p PMID: 33744978 DOI: 10.1007/s00401-021-02297-0

    Year 2020

    Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ

    Arne Ittner, Prita Riana Asih, Amanda R. P. Tan, Emmanuel Prikas, Josefine Bertz, Kristie Stefanoska, Yijun Lin, Alexander M. Volkerling, Yazi D. Ke, Fabien Delerue & Lars M. Ittner

    Acta Neuropathologica (2020) Published: 

    Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature

    Przybyla, M., Van Eersel, J., van Hummel, A., van der Hoven, J., Sabale, M., Harasta, A., Müller, J., Gajwani, M., Prikas, E., Mueller, T., Stevens, C. H., Power, J., Housley, G. D., Karl, T., Kassiou, M., Ke, Y. D., Ittner, A. & Ittner, L. M., Jun 2020, In : Brain. 143, 6, p. 1889-1904 16 p.

    Year 2019

    Neuroinflammation in frontotemporal dementia

    Bright, F., Werry, E. L., Dobson-Stone, C., Piguet, O., Ittner, L. M., Halliday, G. M., Hodges, J. R., Kiernan, M. C., Loy, C. T., Kassiou, M. & Kril, J. J., 1 Sep 2019, In : Nature Reviews Neurology. 15, 9, p. 540-555 16 p.

    Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues

    Ittner, L. M., Klugmann, M. & Ke, Y. D., 1 Sep 2019, In : British Journal of Pharmacology. 176, 18, p. 3649-3665 17 p.

    Year 2018

    Dendritic tau in Alzheimer's disease

    Ittner, A. & Ittner, L. M., 11 Jul 2018, In : Neuron. 99, 1, p. 13-27 15 p.

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