Applied optogenetics to study neurodegeneration
Neurodegenerative diseases represent a growing challenge to global health. Despite research efforts, the underlying mechanisms of neurodegeneration are not fully understood, and there is a critical lack of effective treatments.
This international scholarship aims to develop a zebrafish model that can be used to control neural activities precisely by using optogenetics. The work uses state-of-the-art techniques to develop better therapeutic interventions.
Key details
- 20225203
- PhD
- Applications close on 30 April 2025 at 11pm
- Domestic, International
- Medicine and health, science
- $38,500 p.a. (2025 rate)
About the scholarship
We are excited to offer a PhD scholarship focusing on the study of Motor Neuron Disease (MND), a condition characterised by altered motor neuron excitability.
This project will pioneer the use of an innovative zebrafish optogenetic platform to delve into the early contributors to MND.
A key focus will be understanding how changes in neuron excitability lead to the mislocalisation and aggregation of the MND-hallmark protein, TDP-43.
Project goals:
- investigate the relationship between neuronal activity patterns and neurodegeneration
- utilise cutting-edge optogenetics, advanced imaging techniques, and explore protein aggregation mechanisms within a single, powerful model system.
Our laboratory, home to the largest MND Centre in Australia, boasts extensive experience in these techniques (DOIs: 10.1016/j.redox.2018.08.011; 10.1101/2023.12.11.571038) and provides a supportive, inclusive research environment with ample opportunities for career development.
Research outcomes:
- unravel the molecular and cellular mechanisms linking hyperexcitability to MND in a living organism
- identify how altered excitability contributes to TDP-43 pathology
- open new avenues for therapeutic intervention based on our findings.
This scholarship presents a unique opportunity to contribute to pioneering research that aims to uncover the mysteries of neurodegenerative diseases and pave the way for novel therapeutic strategies.
Join us in our mission to make a significant impact on the understanding and treatment of MND.
Availability
The scholarship is available to candidates eligible to undertake a direct entry three year PhD program.
Components
Each scholarship comprises:
- a tuition fee offset/scholarship
- a living allowance stipend.
The value of each stipend scholarship is $38,500 per annum (full time, indexed) for three years.
How to apply
Applications must include:
- a targeted cover letter
- an up-to-date CV
- a clear outline what the applicant can contribute to the research program.