Funding opportunities

About:

The objectives of this grant opportunity offers funding to support medical research and medical innovation programs of research that deliver a ‘moonshot’ by creating a treatment for a currently serious and incurable health condition, through a series of linked projects. The program of research can propose to develop novel health technologies and/or re-purpose existing health technologies in a novel way.

The process to get funding has two stages:

• Expression of interest – outlining a proposed program of research with a 10-year time horizon
• Full application, for a project of up to five years under the program of research. Full applications may be submitted by invitation only.

Applicants may propose to start research at any stage in the research pipeline from proof-of-concept, with the intention of achieving full implementation of the proposed technology in 10 years.

Funding for subsequent projects under the program of research that continue to progress the technology towards full implementation can be sought by submitting additional full applications to this grant opportunity (i.e. applicants do not need to recommence with an EOI). These applications may be submitted by invitation only.

It is expected that expressions of interest will close on 31 March 2026, with the last grants awarded by 30 June 2027. However, the closing date for expressions of interest may be altered if:

• the available funds are exhausted or insufficient to fund additional grants, in which case the closing date may be brought forward;
• further funds are made available in future years, in which case the closing date may be extended.

Apply Via: Department of Industry, Science and Resources DISR

• Opening date in DISR: 13 February 2023
• Strategic review (optional): four weeks prior to the date you wish to submit, (book via this link)
• Compliance and eligibility check (mandatory): two weeks prior to the date you wish to submit, (book via this link)
• Applicant submits final application in DISR: When application is compliant and all approvals are obtained in PURE

About:

The objective of this grant opportunity is to provide grants of financial assistance to support medical research and medical innovation projects that:

• promote Australian involvement in international collaborative investigator-initiated clinical trials
  research through the establishment and co-ordination of clinical trial site/s in Australia.
• provide high-quality evidence of the effectiveness of novel health treatments, drugs or devices in
  ‘usual care’ settings, which will support a decision on whether to deliver the intervention in an
  Australian setting.

The intended outcome of the research funded by this grant opportunity is to improve the health and wellbeing of Australians by investing in new clinical trials that support increased access to high-quality, evidence-based and effective health care.

This grant opportunity is intended to support projects that progress research that addresses a specific
health need. For the purposes of this grant opportunity, novel health treatments can include innovative applications of
existing interventions.

Applications to this grant opportunity must propose a clinical trial in Australia in collaboration with
international counterparts. The clinical trial should not have commenced recruitment at the Australian trial
site/s.

NOTE: Applicants must nominate a Chief Investigator A (CIA) who will take the lead role in completing the
application, conducting the research, and reporting as required under the grant agreement.

A person must not be named as a Chief Investigator (CI) on more than one application submitted to a
Round of this grant opportunity (i.e. a person may be named as a CI on a maximum of one application
per Round). If a CI is named on more than one application submitted to a Round of this grant opportunity,
both applications will be considered ineligible.

Funds Available and Period:

The maximum amount available for a single grant is $3.0 million and maximum grant period that can be applied for is five years.

Managing agency: MRFF (via Sapphire)

• MRFF Opening Date: 6 March 2024
• Strategic review (optional): On or before  06 Jan 2025 (book via this link)
• Minimum Data Due: : 5pm ACT local time on 4 December 2024
• Compliance and Eligibility check (mandatory): On or before 07 Jan 2025 (book via this link)
• Applicant submits final application in PURE: Sunday 02 Feb 2025
• Research Services submission to MRFF: 5pm ACT local time on 5 February 2025

About:

The objective of this grant opportunity is to provide grants of financial assistance to support Australian medical research and medical
innovation projects that:

• Stream 1 - Innovation enablers (Targeted Call for Research)
  address an area of unmet medical need by promoting the development and implementation of
  new research infrastructure by supporting development and/or expansion of research enablers
  such as biobanks, tissue repositories, novel research platforms, and secure health data
  environments to create valuable research resources.
• Stream 2 - Digitisation of health care (Targeted Call for Research)
  develop and translate into practice digital therapeutics, artificial intelligence enabled health
  interventions and technologies (e.g. wearables integrated into clinical practice), applications or
  other software for use in clinical practice.
• Stream 3 - Co-investment partnerships (Targeted Call for Research)
  utilise co-investment (cash only) with the research sector, state and/or territory governments,
  and industry, in significant critical research infrastructure (e.g. facilities, personnel and
  equipment):
  • to support development of research capacity, capability and/or effectiveness in an area of
    unmet medical need, or
  • to enable Australian research using new platforms, systems and services in an area of
    unmet medical need.
• Stream 4 - mRNA technology enablers (Targeted Call for Research)
  leverage and enhance emerging mRNA technologies, platforms, and/ or equipment to
  accelerate develop

Additional information for Stream 2 For applications to Stream 2, artificial intelligence technologies may include machine learning, natural language processing, speech recognition, computer vision, and automated reasoning techniques.

Additional information for Stream 3
Stream 3 is structured to incentivise partnerships between academia, governments and industry that can generate knowledge and/or interventions that can transform health practice.

Additional information for Streams 3 and 4
For the purposes of Streams 3 and 4 of this grant opportunity, ‘platforms, systems and services’ may include:  tools for enabling interdisciplinary research cooperation (‘platforms’)  artificial intelligence, software, quality control research management (‘systems’)  provision of scientific or technical expertise and resources; skilled personnel required to run facilities, systems, equipment and platforms; capability building; and professional development (‘services’).

Applications to this grant opportunity must propose research that addresses one of the four Streams of research. An application may only be submitted to one of the above four Streams only. Applicants must specify the Stream to which they are applying in their application.

The intended outcome of the research funded by this grant opportunity is to improve the health and wellbeing of Australians by enhancing Australia’s research infrastructure to promote new research approaches that will address health challenges by generating new knowledge and improving health outcomes.

Funds Available and Period:

• Stream 1 (Targeted Call for Research):The maximum amount available for a single grant is $3 million.
• Stream 2 (Targeted Call for Research): The maximum amount available for a single grant is $3 million.
• Stream 3 (Targeted Call for Research): The maximum amount available for a single grant is $7 million. Grants funded under Stream 3 will be funded under a co-funding model.
• Stream 4 (Targeted Call for Research): The maximum amount available for a single grant is $4 million.

Note:  All members of the research team must be listed on the application form as Chief Investigators (CIs). Applicants must nominate a Chief Investigator A (CIA) who will take the lead role in conducting the project and report on the outcomes of the project as specified in the grant agreement.

To facilitate collaborative research teams with the required capacity and capability to undertake the proposed research, up to 15 CIs may be included as members of the research team. If you include more than 15 CIs, your application will be ineligible.

A person must not be named as a Chief Investigator (CI) on more than one application submitted per stream to this grant opportunity. If a person is named as a CI on more than one application per stream, all of those applications will be considered ineligible.

Apply Via: Department of Industry, Science and Resources DISR

• Opening Date: 4-Oct-2024
• Strategic review (optional): On or before 03 March 2025 (book via this link)
• Compliance and Eligibility check (mandatory): On or before 17 March 2025 (book via this link)
• Applicant submits final application in DISR: When application is compliant and all approvals are obtained in PURE 5 pmACT local time on 5 February 2025

About:

The objective of this grant opportunity is to provide grants of financial assistance to support medical research and medical innovation projects that evaluate the effectiveness and feasibility of new or existing models of integrated, multidisciplinary team-based primary care for people who would most benefit from this type of care, including but not limited to First Nations Australians, people from culturally and linguistically diverse backgrounds, people with disability including intellectual, children, older populations (either in residential aged care homes or those ageing at home), or those with social disadvantage or multiple chronic conditions.
Cross-jurisdictional collaboration, where relevant, is encouraged and projects should consider sustainability and scalability of solutions beyond the project.

Three streams of funding are available based on the health service provider or geographic location of the organisation undertaking the majority of the research:

• Stream 1 (Targeted Call for Research): The organisation undertaking the majority of the research must be located in any area according to the Modified Monash Model (MM1-7)
• Stream 2 (Targeted Call for Research): The organisation undertaking the majority of the research is located in, and the Chief Investigator A and 50% or more of all Chief Investigators, and all research participants, are primarily resident in, a rural or remote area according to the Modified Monash Model (MM3-7)
• Stream 3 (Targeted Call for Research): The organisation undertaking the majority of the research must be an Aboriginal Community Controlled Health Service.

For all Streams, applications must clearly demonstrate activities for capacity building for primary care practitioners and early career clinicians and/or researchers including salary stipends for PhD scholarships or clinician time where relevant.

NOTE: Applicants should note the additional eligibility criteria that apply to individuals or organisations for this grant opportunity.

Applicants must nominate a Chief Investigator A (CIA) who will take the lead role in completing the application, conducting the research, and reporting as required under the grant agreement.

A person must not be named as a Chief Investigator (CI) on more than one application submitted to a Stream of this grant opportunity (i.e. a person may be named as a CI on a maximum of one application per Stream). If a CI is named on more than one application submitted to a Stream of this grant opportunity, both applications will be considered ineligible.

Funds Available and Period:

The amounts available for a single grant in each Stream are as follows: 

Stream 1: The maximum amount available for a single grant is $2.0 million; the maximum grant period is 5 years
Stream 2: The maximum amount available for a single grant is $2.0 million; the maximum grant period is 5 years
Stream 3: The maximum amount available for a single grant is $2.0 million; the maximum grant period is 5 years

Managing agency: MRFF (via Sapphire)

• MRFF Opening Date: 11 September 2024
• Strategic review (optional): On or before  03  March 2025 (book via this link)
• Minimum Data Due: : 5:00pm (ACT Local Time) on 5 March 2025
• Compliance and Eligibility check (mandatory): On or before 19 March 2025 (book via this link)
• Applicant submits final application in PURE: Sunday 30 March 2025
• Research Services submission to MRFF: Updated from 2 April 2025 5:00pm (AEDT) to 9 April 2025 5:00pm (AEST).

About:

The objective of this grant opportunity is to provide grants of financial assistance to support medical research and medical innovation projects that:

• Stream 1 (Targeted Call for Research): conduct a pilot study to assess the feasibility of a new clinical trial for one or more treatments and/or management strategies for a rare cancer, rare disease and/or unmet need.
• Stream 2 (Targeted Call for Research): conduct a clinical trial of one or more treatments and/or management-based interventions for rare cancers, rare diseases and/or unmet need.
• Stream 3 (Targeted Call for Research): conduct a clinical trial that assesses the comparative effectiveness of two or more health interventions to treat a specific clinical condition, to inform the decisions of policy makers, clinicians, and consumers regarding healthcare and to minimise the use of unnecessary, ineffective, and harmful health interventions.
• Stream 4 (Targeted Call for Research): conduct an implementation science trial to determine the best ways to implement a proven preventive health intervention, screening or diagnostic test, therapeutic agent, technology or model of care that is not in routine use in Australia.

This grant opportunity is intended to support projects that progress research that addresses a specific health need.
Applicant's should note the additional eligibility criteria that apply to individuals or organisations for this grant opportunity.

NOTE: Applicants must nominate a Chief Investigator A (CIA) who will take the lead role in completing the application, conducting the research, and reporting as required under the grant agreement.

A person must not be named as a Chief Investigator (CI) on more than one application submitted to a Stream of this grant opportunity (i.e. a person may be named as a CI on a maximum of one application per Stream). If a CI is named on more than one application submitted to a Stream of this grant opportunity, both applications will be considered ineligible.

Grant period and Grant amount :

The maximum grant period and grant amount that can be applied for in each Stream is as follows:

• Stream 1: 2 years and the maximum amount available for a single grant is $0.8 million.
• Stream 2: 7 years and  the maximum amount available for a single grant is $5.0 million.
• Stream 3: 7 years and the maximum amount available for a single grant is $5.0 million.
• Stream 4: 7 years and the maximum amount available for a single grant is $5.0 million.

Managing agency: MRFF (via Sapphire)

• MRFF Opening Date: 4 September 2024
• Strategic review (optional): On or before 5 March 2025 (book via this link)
• Compliance and Eligibility check (mandatory): On or before 19 March 2025 (book via this link)
• Applicant submits final application in PURE: Sunday 30 March 2025
• Minimum Data Due: : 5:00pm (ACT Local Time) on 5 March 2025
• Research Services submission to MRFF: Updated from 2 April 2025 5:00pm (AEDT) to 9 April 2025 5:00pm (AEST).

About:

This objective of this grant opportunity will support medical research and medical innovation projects that:
Stream 4 (Aim 3 of Research Plan):

• Stage 2 (Targeted Call for Research): establish a multidisciplinary national adaptive platform trial that accelerates assessment and implementation of therapeutic interventions (pharmacological and non-pharmacological) for PASC.

The intended outcome of the research funded by this grant opportunity is to improve the health and wellbeing of Australians by:

• Stream 4 (Aim 3 of Research Plan; Incubator and Targeted Call for Research): accelerating the identification of optimal management approaches for people living with PASC.

This grant opportunity is being administered by NHMRC on behalf of the Australian Government Department of Health and Aged Care.

NOTE: Additional information applies for Stream 4

Applicants must nominate a Chief Investigator A (CIA) who will take the lead role in completing the application, conducting the research, and reporting as required under the grant agreement. Applications to Stage 2 of Stream 4 can include Chief Investigators that were successful under Stage 1. Otherwise, a person must not be named as a Chief Investigator (CI) on more than one application submitted to a Stream of this grant opportunity (i.e. a person may be named as a CI on a maximum of one application per Stream).

Funds Available and Period:

The maximum grant duration for Stream 4 Stage 2 is 5 years

Managing agency: MRFF (via Sapphire)

• MRFF Opening Date: 06 September 2023
• Strategic review (optional): On or before )1 April 2025 (book via this link)
• Minimum Data Due: : 5:00pm (ACT Local Time) on 5 March 2025
• Compliance and Eligibility check (mandatory): On or before 16 April 2025 (book via this link)
• Applicant submits final application in PURE: Sunday 27 April 2025
• Research Services submission to MRFF: 5pm ACT local time on 30 April 2025

About:

The objective of this grant opportunity is to provide grants of financial assistance to support medical research and medical innovation projects that:

• Stream 1 (Targeted Call for Research): develop consumer-informed approaches to generating and/or incorporating consumer/patient data across the health technology assessment lifecycle of medicines or vaccines.
• Stream 2 (Targeted Call for Research): develop consumer-informed approaches to generating and/or incorporating consumer/patient data across the health technology assessment lifecycle of medical devices.
• Stream 3 (Targeted Call for Research): develop scalable and sustainable approaches to evaluating the long-term effectiveness of highly specialised therapies, emerging medicines, or medicine-related health technologies, including the incorporation of patient reported outcomes.
• Stream 4 (Targeted Call for Research): develop approaches to generating and/or incorporating patient reported outcomes into the assessment of the long-term safety and efficacy and/or the material safety and biocompatibility of implantable devices. This grant opportunity is intended to support projects that progress research that addresses a specific health need. Applicants to Streams 1 and 2 can propose research that considers any part of the health technology assessment lifecycle

This grant opportunity is intended to support projects that progress research that addresses a specific health need.

Applicants to Streams 1 and 2 can propose research that considers any part of the health technology assessment lifecycle.

Additional information for all Streams

All applications are required to:

• be co-designed with consumers, including patients/carers and/or community representatives.
• be conducted in partnership with health professionals/service providers, academic researchers, product makers (industry), and/or policy makers.
• consider the safety, accessibility, effectiveness, cost-effectiveness, and long-term clinical outcomes (as appropriate) in the research design.

The intended outcome of the research funded by this grant opportunity is to improve the health and wellbeing of Australians by:

• Stream 1 (Targeted Call for Research): enhancing health technology assessment and decision making through incorporation of patient data.
• Stream 2 (Targeted Call for Research): enhancing health technology assessment and decision making through incorporation of patient data.
• Stream 3 (Targeted Call for Research): improving evaluation of the long-term effectiveness of highly specialised therapies, emerging medicines, or medicine-related health technologies.
• Stream 4 (Targeted Call for Research): improving long-term safety and health outcomes for patients using implantable medical devices.

Note: Applicants must nominate a Chief Investigator A (CIA) who will take the lead role in completing the application, conducting the research, and reporting as required under the grant agreement.

A person must not be named as a Chief Investigator (CI) on more than one application submitted to a Stream of this grant opportunity (i.e. a person may be named as a CI on a maximum of one application per Stream). If a CI is named on more than one application submitted to a Stream of this grant opportunity, both applications will be considered ineligible.

Funds Available and Period:

The maximum amounts available for a single grant in each Stream is $2.0 million and the maximum grant period that can be applied for each Stream  is 5 years

Managing agency: MRFF (via Sapphire)

• MRFF Opening Date: 19 February 2025
• Strategic review (optional): On or before 25 June 2025 (book via this link)
• Minimum Data Due: : 5pm ACT local time on 25 June 2025
• Compliance and Eligibility check (mandatory): On or before 9 July 2025 (book via this link)
• Applicant submits final application in PURE: Sunday 20 July 2025
• Research Services submission to MRFF: 5pm ACT local time on 23 July 2025

About:

The objective of this grant opportunity is to provide grants of financial assistance to support medical research and medical innovation projects that, through co-design with consumers and health services, develop scalable and sustainable interventions to mitigate the impact of climate change on Australians’ mental health.

This grant opportunity is intended to support projects that progress research that addresses a specific health need. To be competitive for funding, applicants must propose to conduct research that delivers against the above objective and those of the Global Health Initiative. Applicants are encouraged to propose novel and/or innovative research and describe how the outcomes of the research will be translated into health benefits for Australians.

The intended outcome of the research funded by this grant opportunity is to improve the health and wellbeing of Australians by addressing the mental health impacts of climate change.

Note: Applicants must nominate a Chief Investigator A (CIA) who will take the lead role in completing the application, conducting the research, and reporting as required under the grant agreement. A person must not be named as a Chief Investigator (CI) on more than one application submitted to this grant opportunity (i.e. a person may be named as a CI on a maximum of one application to this grant opportunity). If a CI is named on more than one application submitted to this grant opportunity, both applications will be considered ineligible.

Funds Available and Period:

The minimum amount available for a single grant is $0.25 million and the maximum amount available for a single grant is $2.0 million; the maximum grant period that can be applied for is 5 years.

Managing agency: MRFF (via Sapphire)

• MRFF Opening Date: 19 February 2025
• Strategic review (optional): On or before 25 June 2025 (book via this link)
• Minimum Data Due: : 5pm ACT local time on 25 June 2025
• Compliance and Eligibility check (mandatory): On or before 9 July 2025 (book via this link)
• Applicant submits final application in PURE: Sunday 20 July 2025
• Research Services submission to MRFF: 5pm ACT local time on 23 July 2025

About:

The objective of this grant opportunity is to provide grants of financial assistance to support Australian medical research and medical innovation projects that:

• deliver late stage translational research that is directly relevant to clinical care, health services and/or health practices, which has the potential to be translated into existing policy and practice
• use existing knowledge and evidence to support and accelerate the translation of research findings into improved health care and health interventions
• address a clearly defined gap in best practice health care and health interventions to improve health outcomes, as identified by collaborating health services
• involve all stakeholders relevant to the research and its translation in its conceptualisation, design and implementation, including health care consumers and providers.

Two streams of funding are available:

• Stream 1 (Accelerator): the Chief Investigators are primarily resident in any area according to the Modified Monash Model (MM1-7)
• Stream 2 (Accelerator): the Chief Investigator A and 50% or more of all Chief Investigators are primarily resident in a regional, rural, or remote area according to the Modified Monash Model (MM2-7).

For this grant opportunity, an application may be submitted to one of the above two Streams only. Applicants must specify the Stream they are applying for in their application.

An organisation may submit more than one application to a single Stream, but there are restrictions on the number of applications an individual (i.e. Chief Investigator) may submit to a single Stream (refer the Section on Chief Investigators in the grant opportunity guidelines).

Funds Available and Period:

The funding available under each Stream is as follows:

Stream 1 (Accelerator): up to $15.0 million ($4.0 million in 2025-26, $10.0 million in 2026-27 and $1.0 million in 2027-28)

Stream 2 (Accelerator): up to $15.0 million ($4.0 million in 2025-26, $10.0 million in 2026-27 and $1.0 million in 2027-28)

Apply Via: Department of Industry, Science and Resources DISR

• Opening Date: 10 February 2025
• Strategic review (optional): On or before 10 June 2025 (book via this link)
• Compliance and Eligibility check (mandatory): On or before 23 June 2025 (book via this link)
• Applicant submits final application in DISR: When application is compliant and all approvals are obtained in PURE before  5pm ACT local time on7 July 2025
• Closing Date and time: 5pm AEST on 7 July 2025

About:

The objective of this grant opportunity is to provide grants of financial assistance to support medical research and medical innovation projects that:

• Stream 1 (Incubator): Conduct early stage, small scale research, led by early career researchers, that seeks to assess the potential and feasibility of novel strategies to address a critical or intractable health issue in one or more Priority Populations.
• Stream 2 (Accelerator): establish a large-scale interdisciplinary research program, led by mid-career researchers, that drives implementation of substantial improvements to health care and/or health system effectiveness for one or more Priority Populations.
• Stream 3 (Targeted Call for Research): utilise co-funding to accelerate the translation of research led by early to mid-career researchers into policy and practice.

Stream 1 is intended to support early stage, small scale research projects that seek to assess the potential and feasibility of novel strategies to address critical or intractable health issues.

Stream 2 is intended to support large-scale interdisciplinary research programs that drive implementation of substantial improvements to health care and/or health system effectiveness.

Stream 3 is intended to support projects that progress research that addresses a specific health need.

Applicants should note the additional eligibility criteria that apply to individuals or organisations for this grant opportunity.

The intended outcome of the research funded by this grant opportunity is to improve the health and wellbeing of Australians by:

• Stream 1 (Incubator): supporting early career researchers to develop innovative solutions for addressing significant health challenges in Priority Populations.
• Stream 2 (Accelerator): supporting mid-career researchers to transform health practice and/or policy for Priority Populations.
• Stream 3 (Targeted Call for Research): supporting early to mid-career researchers to translate new health solutions into practice.

Grant amount and Funding period:

• Stream 1: The minimum amount available for a single grant is $200,000 and the maximum amount available for a single grant is $1.0 million and maximum grant period is 2 years
• Stream 2: The minimum amount available for a single grant is $2.0 million and the maximum amount available for a single grant is $4.0 million and the maximum grant period is 4 years
• Stream 3: There is no minimum grant amount and the maximum amount available for a single grant is $1.0 million and maximum grant period is 3 years.

Key Dates and Managing agency: MRFF (via Sapphire)

• Opening Date: 17 February 2025
• Strategic review (optional): On or before 25 June 2025 (book via this link)
• Minimum Data: 5:00pm (ACT Local Time) on 25 June 2025
• Compliance and Eligibility check (mandatory): On or before 9 July 2025 (book via this link)
• Applicant submits final application in PURE: Sunday 20 July 2025
• Research Services submission to MRFF: 5pm ACT local time on 23 July 2025

About:

The objective of this grant opportunity is to provide grants of financial assistance to support Australian medical research and medical innovation projects that:

• Stream 1: address an area of unmet medical need by promoting the development and implementation of adaptive platform trials. Funding under Stream 1 is available as follows:
  
  Topic A (Incubator): conducting inception projects that build evidence and capability to demonstrate the feasibility of establishing a national adaptive platform trial that would allow for rapid assessment of pharmacological and/or non-pharmacological interventions in an area of unmet need.
  Topic B (Targeted Call for Research): establishing a new national adaptive platform trial that addresses an area of unmet need, including set up of central infrastructure and conduct of initial launch domains.
  Topic C (Targeted Call for Research): expanding an existing adaptive platform trial by adding new domains that address an area of unmet need.
• Stream 2 (Targeted Call for Research): conduct a registry-based randomised controlled trial in an area of unmet medical need by embedding a registry-based randomised controlled trial into a pre-existing clinical registry.
• Stream 3 (Targeted Call for Research): establish a new clinical trial practice network or extend an existing clinical trial practice network to consolidate and strengthen sector capability in clinical trials and collaboration, with the aim of embedding evidence-based care in the health system and improving health outcomes, in an area of unmet medical need

NOTE:
Applicants should note the additional eligibility criteria that apply to individuals or organisations for this grant opportunity.

A person must not be named as a Chief Investigator (CI) on more than one application submitted to a Stream of this grant opportunity (i.e. a person may be named as a CI on a maximum of one application per Stream). If a CI is named on more than one application submitted to a Stream of this grant opportunity, both applications will be considered ineligible.

Grant amount and Funding period:

The amounts available for a single grant are as follows:

• Stream 1:
  Topic A (Incubator): The maximum amount available for a single grant is $0.3 million and maximum period is 1 year.
  Topic B (Targeted Call for Research): The maximum amount available for a single grant is $5.0 million and the maximum period is 7 years.
  Topic C (Targeted Call for Research): The maximum amount available for a single grant is $3.0 million and the maximum period is  7 years
• Stream 2 (Targeted Call for Research): The maximum amount available for a single grant is $1.5 million and maximum period is 7 year.
• Stream 3 (Targeted Call for Research): The maximum amount available for a single grant is $7.0 million and maximum period is 7 year.

Key Dates and Managing Agency:

Apply Via: Department of Industry, Science and Resources DISR

• Opening Date: 13 February 2025
• Strategic review (optional): On or before 20 June 2025 (book via this link)
• Compliance and Eligibility check (mandatory): On or before 3 July 2025 (book via this link)
• Applicant submits final application in DISR: When application is compliant and all approvals are obtained in PURE before 5pm ACT local time on 7 July 2025
• Closing Date and time: 5.00pm AEST on 17 July 2025

About:

The objective of this grant opportunity is to provide grants of financial assistance to support Australian medical research and medical innovation projects that:

• Stream 1 (Priority area 2.3; Targeted Call for Research) conduct implementation research focused on addressing inequalities in uptake of prevention activities for:
  • Topic A: Aboriginal and Torres Strait Islander people
  • Topic B: rural, regional and remote populations
  • Topic C: culturally and linguistically diverse populations.
• Stream 2 (Priority area 3.1; Targeted Call for Research): conduct implementation research to understand the barriers and enablers to, and impact of, the adoption of the key components of high-quality care for older Australians across:
  • care settings
  • population groups (either by disease type, age group or other characteristic).

This grant opportunity is intended to support projects that progress research that addresses a specific health need.
Additional information for Stream 1 Applicants to Stream 1 must select one topic as the primary focus of the application; however, it is anticipated that the proposed research may apply across more than one of the vulnerable populations identified.

Applications to this grant opportunity must propose research that addresses one of the two Streams of research. An application may only be submitted to one of the above two Streams. Applicants must specify the Stream and (for Stream 1) Topic to which they are applying in their application.

The intended outcome of the research funded by this grant opportunity is to improve the health and wellbeing of Australians by:

Stream 1 (Priority area 2.3; Targeted Call for Research): implementing interventions that extend healthy, active years of life amongst vulnerable populations.

Stream 2 (Priority area 3.1; Targeted Call for Research): improving implementation of best practice care for older Australians

Note: A person must not be named as a Chief Investigator (CI) on more than one application submitted to a Stream of this grant opportunity (i.e. a person may be named as a CI on a maximum of one application per Stream). If a CI is named on more than one application submitted to a Stream of this grant opportunity, both applications will be considered ineligible.

Grant Amount and Funding Period

The amounts available for a single grant in each Stream are as follows: -

Stream 1: The maximum amount available for a single grant is $3.0 million and maximum grant period that can be applied for is 5 year 
Stream 2: The maximum amount available for a single grant is $5.0 million and maximum grant period that can be applied for is 5 year

Key Dates and Managing agency: MRFF (via Sapphire)

• MRFF Opening Date: 28 February 2025
• Strategic review (optional): On or before 22 July 2025 (book via this link)
• Minimum Data Due: : 5pm ACT local time on  23 July 2025
• Compliance and Eligibility check (mandatory): On or before 6 August 2025 (book via this link)
• Applicant submits final application in PURE: Sunday 17  August 2025
• Research Services submission to MRFF: 5pm ACT local time on 20 August 2025

About:

The objective of this grant opportunity is to provide grants of financial assistance to support Australian medical research and medical innovation projects that:

• Stream 1 (Priority Area 1.2; Targeted Call for Research): reduce the number of Australians experiencing cardiovascular disease and stroke by developing and implementing early, more effective preventive health interventions, by co-designing and developing strategies with Aboriginal and/or Torres Strait Islander people to embed best-practice, culturally secure cardiovascular disease and stroke prevention for Aboriginal and/or Torres Strait Islander people into care.
• Stream 2 (Priority Area 2.2; Targeted Call for Research): conduct Phase 1 and Phase 2 clinical trials to demonstrate safety and potential efficacy of novel devices and therapeutic approaches for cardiovascular disease and stroke.
• Stream 3 (Priority Area 3.2; Targeted Call for Research): conduct a large-scale multiomics project focused on improving understanding of recovery trajectories and phenotypes, underpinning recovery and survivorship in cardiovascular disease and stroke.
• Stream 4 (Priority Area 1.2; Targeted Call for Research): reduce the number of Australians experiencing cardiovascular disease and stroke by developing and implementing early, more effective preventive health interventions.

Funding under Stream 4 is available as follows:

• Topic A: developing and implementing novel therapeutics/technologies for the prevention of cardiac disease caused by chronic diseases
• Topic B: developing and implementing novel discoveries and markers to improve risk prediction
• Topic C: developing and implementing novel approaches to tailor preventive care, support adherence and reduce inequalities.

NOTE: A person must not be named as a Chief Investigator (CI) on more than one application submitted to a Stream of this grant opportunity (i.e. a person may be named as a CI on a maximum of one application per Stream). If a CI is named on more than one application submitted to a Stream of this grant opportunity, both applications will be considered ineligible.

The anticipated outcomes of the research are to improve the health and wellbeing of Australians by:

• Stream 1 (Priority Area 1.2; Targeted Call for Research): improving uptake of best-practice and culturally safe cardiovascular disease and stroke prevention for Aboriginal and/or Torres Strait Islander people.
• Stream 2 (Priority Area 2.2; Targeted Call for Research): generating evidence to improve treatments and interventions for cardiovascular disease and stroke.
• Stream 3 (Priority Area 3.2; Targeted Call for Research): improving the recovery and survivorship of people with cardiovascular disease or stroke.
• Stream 4 (Priority Area 1.2; Targeted Call for Research): reducing the incidence of cardiovascular disease and stroke through better prevention.

Grant amount and Funding period:

The amounts available for a single grant in each Stream are as follows:

Stream 1: The maximum amount available for a single grant is $2.0 million and the maximum period of funding is 5 year.
Stream 2: The maximum amount available for a single grant is $3.0 million and the maximum period of funding is 7 year
Stream 3: The minimum amount available for a single grant is $3.0 million and the maximum amount available for a single grant is $5.0 million and  the maximum period of funding is 7 year
Stream 4: The maximum amount available for a single grant is $3.0 million and the maximum period of funding is 5 year

Key Dates and Managing agency: MRFF (via Sapphire)

• MRFF Opening Date: 14 February 2025
• Strategic review (optional): On or before 14 July 2025 (book via this link)
• Minimum Data Due: 5pm ACT local time on 16 July 2025
• Compliance and Eligibility check (mandatory): On or before 30 July 2025 (book via this link)
• Applicant submits final application in PURE: Sunday 10  August 2025
• Research Services submission to MRFF: 5pm ACT local time on 13 August 2025

About:

The objective of this grant opportunity is to provide grants of financial assistance to support Australian medical research and medical innovation projects that:

• Promote Australian involvement in international collaborative investigator-initiated clinical trials research through the establishment and co-ordination of clinical trial site/s in Australia.
• Provide high-quality evidence of the effectiveness of novel health treatments, drugs or devices in ‘usual care’ settings, which will support a decision on whether to deliver the intervention in an Australian setting.

The intended outcome of the research is to improve the health and wellbeing of Australians by investing in new clinical trials that support increased access to high-quality, evidence-based and effective health care.

Applications where international collaboration provides for the successful conduct of clinical trials that may otherwise not be feasible in Australia are particularly encouraged.

NOTE: A person must not be named as a Chief Investigator (CI) on more than one application submitted to a Round of this grant opportunity (i.e. a person may be named as a CI on a maximum of one application 12 per Round). If a CI is named on more than one application submitted to a Round of this grant opportunity, both applications will be considered ineligible.

Grant amount and Funding period:

The maximum amount available for a single grant is $3.0 million and maximum grant period that can be applied for is 7 years.

Key Dates and Managing agency: MRFF (via Sapphire):

Round  1

• MRFF Opening Date: 20 February 2025
• Strategic review  Round 1 (optional): 5pm ACT local time on 1 July 2025 (book via this link)
• Minimum Data Due: : 5pm ACT local time on 2 July 2025
• Compliance and Eligibility check Round 1 (mandatory): On or before 15 July 2025 (book via this link)
• Applicant submits final application in PURE: Sunday  27 July 2025
• Research Services submission to MRFF: 5pm ACT local time on 30 July 2025

Round 2

• MRFF Opening Date: 20 February 2025
• Strategic review  Round 2 (optional): 5pm ACT local time on 5 Jan 2026 (book via this link)
• Minimum Data Due: 5pm ACT local time on 10 December 2025
• Compliance and Eligibility check Round 2 (mandatory): On or before 15 January 2026 (book via this link)
• Applicant submits final application in PURE: Sunday 01 Feb  2026
• Research Services submission to MRFF: Round 2: 5pm ACT local time on 4 February 2026

Lead Chief Investigator: Professor Jeffrey Braithwaite
Project title: Harnessing implementation science, complexity science and evidence-based care to Keep Australians Out of Hospital: leveraging seven natural experiments in New South Wales
Scheme: Keeping Australians out of Hospital
Funding total: $1,505,612

Lead Chief Investigator: Professor Ralph Martins
Project title: The Australian-multidomain Approach to Reduce dementia Risk by protecting brain health With lifestyle intervention (AU-ARROW) study
Scheme: MRFF International Clinical Trial Collaborations (ICTC) Program
Funding total: $3,115,063

Lead Chief Investigator: Professor Deborah Schofield
Project title: The health, economic and social consequences of genomic sequencing and cascade testing for intellectual disability.
Scheme: MRFF Genomics Health Futures Mission – Ethical, Legal and Social Issues Projects Grant
Funding total: $499,728

Lead Chief Investigator: Professor Viviana Wuthrich
Project title: Screening and Risk Reduction for Dementia in Primary Care
Scheme: 2020 Investigator Grants: MRFF Priority Round to commence in 2021 (EL2)
Funding total: $1,562,250

Lead Chief Investigator: Professor Catherine McMahon
Project title: Improving care pathways for Otitis Media in Aboriginal children (0-12): A case study approach
Scheme: 2019 MRFF Indigenous Health Research 2020
Funding total: $1,961,473.90

Lead Chief Investigator: Professor Sheila Degotardi
Project title: Harnessing the health communication power of the early childhood sector
Scheme: Coronavirus Research Response – 2020 Communication Strategies and Approaches During Outbreaks
Funding total: $174,992

Lead Chief Investigator: Professor Simon French
Project title: Determining the impact of a new primary care model for low back pain: A cluster randomised trial
Scheme: MRFF International Clinical Trial Collaborations (ICTC) Program
Funding total: $2,107,805.90

Lead Chief Investigator: Professor Piers Dawes
Project title: SENSEcog aged care: Hearing and vision support to improve quality of life for people living with dementia in residential aged care
Scheme: MRFF 2020 Dementia, Ageing and Aged Care Grant
Funding total: $1,200,710.20

Lead Chief Investigator: Professor Helen Rizos
Project title: Integrated Multimodal Precision Liquid biopsy to Enhance MElanoma and NSCLC Treatment (IMPLEMENT)
Scheme: MRFF 2020 Genomics Health Futures Mission
Funding total: $2,031,178.80

Lead Chief Investigator: Associate Professor Robyn Clay-Williams
Project title: Working together: innovation to improve Emergency Department (ED) performance, and patient outcomes and experience for five complex consumer cohorts
Scheme: 2022 MRFF Models of Care to Improve the Efficiency and Effectiveness of Acute Care
Funding total: $2,836,550.50

Lead Chief Investigator: Professor Johanna Westbrook
Project title: Transforming residential aged care through evidence-based informatics
Scheme: 2021 MRFF Dementia, Ageing and Aged Care Mission
Funding total: $992,386.00

Lead Chief Investigator: Dr Kylie Gwynne
Project title: Early Artial fibrillation Screening for Indigenous people (EASI)
Scheme: 2021 MRFF Cardiovascular Health Mission
Funding total: $574,883.90